Differential Response to Trichloroethylene-Induced Hepatosteatosis in Wild-Type and PPARα-Humanized Mice
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چکیده
منابع مشابه
Differential Response to Trichloroethylene-Induced Hepatosteatosis in Wild-Type and PPARα-Humanized Mice
BACKGROUND Trichloroacetic acid, an oxidative metabolite of trichloroethylene (TRI), is a ligand of the peroxisome proliferator-activated receptor alpha (PPAR) alpha, which is involved in lipid homeostasis and anti-inflammation. OBJECTIVE We examined the role of mouse and human PPARalpha in TRI-induced hepatic steatosis and toxicity. METHODS Male wild-type (mPPARalpha), Pparalpha-null, and ...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 2010
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.1001928